Year:2023   Volume: 1   Issue: 2   Area: Internal Medicine

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RELATIONSHIP BETWEEN CORONARY COLLATERAL DEVELOPMENT AND SCUBE (SIGNAL PEPTIDE-CUB-EGF DOMAIN-CONTAINING PROTEIN) LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE

Burak Ogulcan Yildirim ORCID Icon,Cemil Zencir ORCID Icon

Our study focused on exploring the connection between serum SCUBE1 (Signal Peptide CUB-EGF like Domain Containing Protein) levels and the formation of CCC (Coronary Collateral Circulation) in patients diagnosed with CAD (coronary artery disease). In the study, we included 80 patients who underwent coronary angiography in the cardiology clinic between April 25, 2019 and April 25, 2020. Their mean age was 63.75 ± 10.7 years. Of them, 30 with normal coronary arteries were assigned to Group 1, 19 with CAD to Group 2, and 31 with CAD who developed CCC to Group 3. The mean SCUBE1 level was 30.61±2.6ng/ml in all the patients. There was no significant difference between the groups (P=0.272). As a result, we compared SCUBE1 levels according to the development of CCC in patients with CAD for the first time in the literature. The findings demonstrated that the measurement of SCUBE1 levels alone might be insufficient to predict the development of CCC in patients with CAD. To confirm these results, multicenter studies with larger samples should be conducted.

Keywords: Coronary artery disease, Coronary collateral development, SCUBE1, Signal Peptide CUB-EGF like Domain Containing Protein

10.5281/zenodo.8414505


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