HASHIMOTO'S DISEASE REVISITED: THE ΓΔ T CELL PERSPECTIVEGulam Hekimoğlu
Hashimoto's disease is a prevalent autoimmune disorder characterized by chronic thyroid gland inflammation. With an emphasis on CD4+ and CD8+ T cells, several research has been done on T cells in connection to Hashimoto's disease. Gamma delta (γδ) T cell involvement in the immunological dysregulation of Hashimoto's disease is not well understood, yet. This review aims to comprehensively examine the impact of γδ T cells on the pathophysiology of Hashimoto's disease, exploring their mechanisms of action and discussing their potential as therapeutic targets. The study utilizes a literature review approach based on current literature and available data. γδ T cells are a distinct subgroup with distinct tissue distribution, antigen recognition, and functional characteristics. Recent research suggests they may contribute to the genesis of Hashimoto's disease according to evidence of their existence and altered subsets in thyroid tissue. It may be possible to understand the precise role of γδ T cells in the immunopathogenesis of the disorder by learning more about their interactions with thyroid autoantigens and regulatory capabilities. Based on the reviewed literature and available data, this study highlights the need for further research on the role of γδ T cells in Hashimoto's disease. Understanding their mechanisms of action, interactions with thyroid autoantigens, and regulatory capacities could lead to the development of therapeutic targets for the disease.
Keywords: γδ T cells, Hashimoto's disease, Pathogenesis, Immune dysregulation